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INDICATIONS FOR PGD

  1. A high genetic risk of passing on a hereditary pathology. Such diagnosis is performed for carriers of genetic and chromosomal anomalies. These can be monogenic diseases (autosomal recessive, autosomal dominant, X- or Y-linked diseases) as well as chromosomal anomalies (numerical and structural chromosomal aberrations);

  2. A high risk of aneuploid gamete formation in case of a normal karyotype. In such circumstances, the number of specific chromosomes in preimplantation embryos is analysed. This kind of diagnosis is called preimplantation genetic screening;

  3. The carriage of gene mutations that can entail diseases with late manifestation occurring in adulthood or old age, including mutations predisposing to the development of oncological diseases. PGD may be chosen by spouses to avoid passing on diseases.

  4. Having a child with a haematological disease in need of donor hematopoietic stem cell transplantation for life prolongation;

  5. The carriage of genetic diseases caused by mutations in mitochondrial DNA (mtDNA). Since the zygote receives all mitochondria from an egg cell, these diseases are passed on maternally.

  6. The determination of the gender of an embryo for the purpose of family planning. Since November 2011, it is prohibited by the law of the Russian Federation to choose the gender of preimplantation embryos for transfer without medical indications.
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