Despite significant achievements in infertility treatment, there are still cases in clinical practice when it is impossible to retrieve oocytes suitable for fertilization. The article (Feng R. et al. Mutations in TUBB8 and Human Oocyte Meiotic Arrest // N Engl J Med. 2016 Jan 21;374(3):223–32.) demonstrates that a mutation in the Tubulin gene can lead to a complete failure of oocyte maturation in IVF/ICSI programmes. The cases of non-drug-related "empty follicle" syndrome may be associated with LH receptor mutations (Yuan P. et al. Genetic evidence of ‘genuine’ empty follicle syndrome: a novel effective mutation in the LHCGR gene and review of the literature // Hum Reprod. 2017 Feb 8:1–10). The problem of total fertilization failure in ICSI programmes and the ways for its solution have also been studied in recent years (Yuan P. et al. Genetic evidence of ‘genuine’ empty follicle syndrome: a novel effective mutation in the LHCGR gene and review of the literature//Hum Reprod. 2017 Feb 8:1-10). The achievements made in Molecular Biology and Genetics over the past decades open up new opportunities for infertility treatment.